Phosphodiesterase (PDE)

Phosphodiesterase (PDE) Related Products (321):

By Effects:	Inhibitors (297) Agonists (2) Activators (2) Modulators (2)

Cat. No.	Product Name	Effect	Purity

HY-153192

Nerandomilast	Inhibitor	99.93%
Nerandomilast (BI 1015550) is an orally active inhibitor of PDE4B with an IC₅₀ value of 7.2 nM. Nerandomilast has good safety and potential applications in inflammation, allergic diseases, pulmonary fibrosis, and chronic obstructive pulmonary disease (COPD).

HY-B0312

Dipyridamole	Inhibitor	99.61%
Dipyridamole is an orally active phosphodiesterase (PDE) inhibitor. Dipyridamole also is an antiplatelet agent used in secondary prophylaxis against stroke. Dipyridamole can induce cancer cell-specific apoptosis.

HY-100912

W-7 hydrochloride	Inhibitor	99.96%
W-7 hydrochloride is a selective calmodulin antagonist. W-7 hydrochloride inhibits the Ca²⁺-calmodulin-dependent phosphodiesterase and myosin light chain kinase with IC₅₀ values of 28 μM and 51 μM, respectively. W-7 hydrochloride induces apoptosis and has antitumor activity.

HY-17464

Cilostazol	Inhibitor	99.96%
Cilostazol (OPC 13013) is a potent and selective inhibitor of phosphodiesterase (PDE) 3A, the isoform of PDE 3 in the cardiovascular system, with an IC₅₀ of 0.2 μM.

HY-B0715

Pentoxifylline	Inhibitor	99.92%
Pentoxifylline (BL-191), a haemorheological agent, is an orally active non-selective phosphodiesterase (PDE) inhibitor, with immune modulation, anti-inflammatory, hemorheological, anti-fibrinolytic and anti-proliferation effects. Pentoxifylline can be used for the research of peripheral vascular disease, cerebrovascular disease and a number of other conditions involving a defective regional microcirculation.

HY-106045

Imazodan	Inhibitor	99.38%
Imazodan is a selective inhibitor for phosphodiesterase III (PDE III), which increases myocardial contractility by blocking the cAMP degradation, and improves the contractile function of heart. Imazodan serves also as a peripheral vasodilator.

HY-401913

endo CNTinh-03	Inhibitor	99.96%
Endo CNTinh-03 is inhibitor for the elevation of cAMP and cGMP induced by agonist, such as G protein-coupled receptors, adenylate cyclase, and guanylate cyclase (IC₅₀ is 4 μM). Endo CNTinh-03 inhibits cholera toxin- and Escherichia coli (STa) toxin- induced CFTR chloride current, ameliorates secretory diarrhea in mouse models, and prevents cyst growth in polycystic kidney disease model.

HY-162912

Enpp-1-IN-23	Inhibitor
Enpp-1-IN-23 (compound 27) is an Enpp-1 inhibitor, with IC₅₀ of 1.2 nM. Enpp-1-IN-23 can be used in cancer research.

HY-B0763

Ibudilast	Inhibitor	99.89%
Ibudilast (KC-404; AV-411; MN-166) is a cyclic AMP phosphodiesterase (PDE) inhibitor. Ibudilast has platelet anti-aggregatory effects. Ibudilast can be used for the research of asthma for its inhibitory effects on tracheal smooth muscle contractility. Ibudilast may be a useful neuroprotective and anti-dementia agent counteracting neurotoxicity in activated microglia.

HY-B0523A

Anagrelide hydrochloride	Inhibitor	99.66%
Anagrelide hydrochloride (BL4162A) is a potent inhibitor of phosphodiesterase type III (PDE3) (IC₅₀=36 nM). Anagrelide hydrochloride, an imidazoquinazoline derivative, acts as an inhibitor of platelet aggregation. Anagrelide hydrochloride inhibits bone marrow megakaryocytopoiesis. Anagrelide hydrochloride decreases gastrointestinal stromal tumor (GIST) cell proliferation and promotes their apoptosis in vitro. Anagrelide hydrochloride is a platelet-lowering agent and plays in the antithrombopoietic action.

HY-129490

Enpp-1-IN-1	Inhibitor	99.86%
Enpp-1-IN-1 is an effective selective enpp-1 (nucleotide pyrophosphatase-phosphodiesterase 1) inhibitor.

HY-15426

PF-04957325	Inhibitor	99.55%
PF-04957325 is a highly potent and selective PDE8 inhibitor, with IC₅₀s of 0.7 nM and 0.3 nM for PDE8A and PDE8B, respectively.

HY-14286

Levosimendan	Inhibitor	99.88%
Levosimendan (Simsndan; OR-1259) is a calcium sensitiser used in the management of acutely decompensated congestive heart failure.

HY-147389

Enpp-1-IN-14	Inhibitor	99.87%
Enpp-1-IN-14 (Compound 015) is a potent Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) inhibitor with an IC₅₀ value of 32.38 nM for recombinant human ENPP-1. Enpp-1-IN-14 has anti-tumor activity.

HY-111673

8-CPT-Cyclic AMP sodium	Inhibitor	99.92%
8-CPT-Cyclic AMP (8-CPT-cAMP) sodium is a selective activator of cyclic AMP-dependent protein kinase (PKA). 8-CPT-Cyclic AMP sodium is also a potent inhibitor of the cyclic GMP-specific phosphodiesterase (PDE VA) with an IC₅₀ of 0.9 μM. 8-CPT-Cyclic AMP sodium also inhibits PDE III and PDE IV with IC₅₀Epac and is a potent Epac activator.

HY-12472

Balipodect	Inhibitor	99.47%
Balipodect (TAK-063) is a highly potent, selective and orally active PDE10A inhibitor with IC₅₀ of 0.30 nM; >15000-fold selectivity over other PDEs.

HY-N0579

Fraxin	Inhibitor	99.83%
Fraxin isolated from Cortex Fraxini, is a glucoside of fraxetin and reported to exert potent anti-oxidative stress action, anti-inflammatory and antimetastatic properties. Fraxin shows its antioxidative effect through inhibition of cyclo AMP phosphodiesterase enzyme.

HY-B0140

Aminophylline	Inhibitor	99.90%
Aminophylline is a competitive and non-selective phosphodiesterase (PDE) inhibitor. Aminophylline is a competitive adenosine receptor antagonist. Aminophylline has apulmonary vasodilator action as well as a bronchodilator action and has the potential for asthma research.

HY-18740A

Trequinsin hydrochloride	Inhibitor	99.93%
Trequinsin hydrochloride (HL 725) is an extremely potent inhibitor of platelet CAMP phosphodiesterase (PDE), with an IC₅₀ of 0.25 nM. Trequinsin hydrochloride (HL 725) is an extremely potent inhibitor of the aggregation of human platelets induced in vitro by ADP, collagen, thrombin and epinephrine.

HY-15747

Deltarasin	Inhibitor	99.12%
Deltarasin is an inhibitor of?KRAS-PDEδ interaction with?K_d?of 38 nM for binding to purified PDEδ.

Name
Email *

	Sorry, but the email address you supplied was invalid.